In six months, you will see your bone density stabilize or improve in one or more areas, but more importantly, we guarantee you'll have strong bones. Therefore, if you break a bone, we'll refund your money for all qualifying purchases since your previous bone scan.
See our guarantee for more details.
Product Description:
- Maintains strong bones
- Supports healthy bone density and bone matrix
- Promotes healthy bone marrow
- Supports healthy immunity and healthy inflammation balance
- Activates genes that produce healthy bone collagen
Adequate calcium and vitamin D throughout life, as part of a well-balanced diet, may reduce the risk of osteoporosis. Osteo-MK4® provides additional nutritional support by combining vitamin D3 with MK4®.
To meet people's unique nutritional needs, NBI created three versions of Osteo-K: original Osteo-K® for those who need more calcium, Osteo-K Minis with less calcium, and calcium-free Osteo-MK4. If you're unsure which product is right for you, click here.
Osteo-MK4 provides 45 mg/day of MK4 and 2000 IU/day of vitamin D3.
Clinical Trials: More than 25 clinical trials involving over 7000 people show that MK4 (45 mg/day in divided doses) promotes healthy bone density and maintains strong bones.
One review of data from 19 randomized, controlled clinical trials involving 6,759 volunteers reached the same conclusion: MK4 (45 mg/day in divided doses) maintains bone strength (Huang ZB et al. 2015;26(3):1175-1186).
A more recent systematic review and meta-analysis published in 2022 confirmed these findings. This study pooled data from 10 randomized, controlled clinical trials with 5,413 women ages 45-81. The data showed that clinical trial volunteers taking MK4 had better bone density and stronger bones than those who did not take the nutrient (Ma ML et al. 2022;10:979649).
Studies show that combining MK4 with vitamin D3 provides greater benefits than taking MK4 alone. A two-year clinical trial with 172 women (average age 53 years) divided the volunteers into four groups. They took MK4 (45 mg/day) alone, vitamin D3 alone, or MK4 plus vitamin D3. The fourth group served as a control and received only dietary counseling. All women had low bone mineral density at the beginning of the study.
Bone mineral density increased significantly more in the MK4+D3 group than in the other groups, and this improvement was evident after just six months of taking the nutrients. After two years, 67.8% of volunteers taking MK4+D3 had a bone density increase of 2% or more, while 45.2% had a 5% or greater increase (Ushiroyama T et al. 2002;41(3):211-221).
Another two-year randomized clinical trial divided 92 women (mean age about 64) into four groups. The women took MK4 (45 mg/day) alone, vitamin D3 alone, MK4 (45 mg/day) plus vitamin D3, or calcium alone (as calcium lactate, 2 grams/day). The best results were noted in the volunteers who took MK4 plus D3. In this group, bone density increased 1.49% during the first year and 1.35% after two years. (Iwamoto J, et al. 2000;5(6):546-51.)
A third clinical trial showed MK4 was the key additional nutrient. The study lasted six months and gave 78 women ages 61 to 74 either MK4 (45 mg/day), vitamin D3 and calcium, or only vitamin D3 and calcium. Only those taking MK4 showed increased bone density. (Je SH, et al. 2011;26(8):1093-8.)
Safety: Clinical trials published in medical journals document over 7,000 people taking 45 mg daily (and higher doses) of MK4 for up to eight years without any serious side effects.
CAUTION: People taking the anticoagulant medication warfarin (Coumadin) should not take this product since vitamin K interferes with this medication.
Directions: Take one capsule twice daily with meals.
60 capsules per bottle, a 30-day supply
References: More than 100 citations support Osteo-K, Osteo-K Minis, and Osteo-MK4 ingredients for bone health, cardiovascular health, and immune support.
Dairy Free | Gluten Free | Soy Free