To meet the unique nutritional needs of different people, NBI has created two versions of Osteo-K, the original Osteo-K® formula and Osteo-K Minis (with less calcium). If you're not sure which product is right for you, click here.
Osteo-K delivers 45 mg of MK4® (menaquinone-4) per day in divided doses to more closely match the clinical trials, plus calcium (1000 mg/day) and vitamin D (2000 IU/day).
NBI's MK4 is a natural form of vitamin K2 derived from Orange Jasmine (Murraya paniculata), leaf geraniol extract. As a nutrient, MK4 has many positive effects on the body. Research on MK4 (45 mg/day taken in divided doses) show that it builds stronger bones and promotes healthy blood production in people with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).
Bone Support and Fracture Reduction: Two meta-analyses of clinical trials on MK4 in people with osteoporosis concluded that MK4 (45 mg/day) reduces fracture risk. One of the studies determined that MK4 (45 mg daily) can decrease vertebral fracture risk by 60% and all nonvertebral fractures by 76% (Cockayne S et al. Arch Intern Med. 2006;166(12):1256-1261).
A more recent study published in 2015 evaluated 19 randomized, controlled clinical trials involving 6,759 volunteers. The researchers reached the same conclusion that MK4 (45 mg/day) can reduce fractures in women with osteoporosis (Huang ZB et al. Osteoporosis International. 2015;26(3):1175-1186).
Cancer Support: The US FDA reviewed the research on MK4 (45 mg/day) for people with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The FDA concluded that MK4 has the potential to treat these diseases, and awarded Dr. Neustadt’s company, NBI Pharmaceuticals, Inc. Orphan Drug Designation for MK4 for AML and MDS. As a dietary supplement, MK4 is not approved as a medication to diagnose, treat, prevent or cure any disease, but it can be taken as a dietary supplement to support healthy cell function.
SAFETY: Clinical trials published in medical journals document more than 7,000 people taking 45 mg daily (and higher doses) of MK4 for up to eight years without any serious side effects. The US Institutes of Medicine (IOM) states that natural vitamin K, which includes MK4, has no known “tolerable upper limit,” which means it’s considered safe even in doses much higher than that found in Osteo-K and Osteo-K Minis.
CAUTION: People taking the anticoagulant medication warfarin (Coumadin) should not take this product since vitamin K interferes with this medication.
180 capsules per bottle, a 30-day supply
More than 100 citations support the ingredients in Osteo-K and Osteo-K Minis for bone health, cardiovascular health and cancer support.
Gluten Free | Corn Free | Soy Free | Dairy Free
Osteo-K is the best addition to my bone health. Other forms of Vitamin K are a waste of money and do nothing to address the cause of weak bones due to age. I'm pleased that the Japanese people have shared this. American drug companies don't recognize anything they can't make money on. And so, people like me pay the price. Thank you for this product. My last scan showed improvement! I order large numbers of bottles so I never run out. Keep up the good work!!
Everyone here was excited to learn about your results and how much help Osteo-K has given you. Thank you for sharing your experience with Osteo-K.
I've been using this for 10 years. It has helped with my over-all health and bone density. It's been a "life-saver!"
Thank you for leaving a review and sharing how Sleep Relief has helped you.
I have had back pain for a few years now. Have been using this for past year. I haven’t had any issues with back pain since I started taking it! I will continue using Osteo K. Thank you NBI
I'm so glad Osteo-K is helping you! Thank you for leaving a review and sharing your experience.
Been taking it for last 2 yrs. and scan came out better.
That's fantastic! Thank you for sharing your experience with Osteo-K and leaving a review.
My experience is good. When I placed my last order I asked when they were going to have a sale. They said they just had one in January. I always get an email from you for sales. I never received one this time and I was not too happy. When I order, I order a lot and the discount makes it great. So I ordered not so much this time. I hope I get an email when you have your next sale. I have been ordering from you for a long time. Hope the sale is on when I need to order again. Thanks. Robin Culley
I'm glad Osteo-K is working for you. I'm sorry you didn't receive the last NBI sale announcement. We always announce our sales in our weekly newsletters. I checked and you are on the email list. It shows that you've been receiving the emails, so I'm not sure what happened during the last sale. You've been an NBI customer for a long time and I'm sorry you didn't get to take advantage of our last sale. Therefore, I'm going to apply the sale discount to your last order. You should receive an email from the NBI store soon that your last order has been partially refunded. Thank you for allowing NBI to be part of your healthcare routine.
This product is very well tolerated and has save me from the fear of having to take Fosamax or some other detrimental therapy for osteoporosis. I am extremely happy with this option and very hopeful.
Thank you for your review and choosing Osteo-K to part of your health routine.
Using it for years. Even doctor thought this was a better product than he was using.
Thank you for your review. I'm glad your doctor also recognized the quality of the Osteo-K formula and that Osteo-K is helping you.
Recomended by my Doctor Been using it for years
I am faithful to take my Osteo-K, as I have osteoporosis and want to keep it from getting worse.
Thank you for leaving a review.
Osteo K has improved my bone density by 6% in less than a year. I am 52 years old and have moderate osteoporosis. I am thankful for this product. I do not want to take prescription drugs for osteoporosis.
Thank you for the review.