To meet the unique nutritional needs of different people, NBI has created two versions of Osteo-K, the original Osteo-K® formula and Osteo-K Minis (with less calcium). If you're not sure which product is right for you, click here.
Osteo-K delivers 45 mg of MK4® (menaquinone-4) per day in divided doses to more closely match the clinical trials, plus calcium (1000 mg/day) and vitamin D (2000 IU/day).
NBI's MK4 is a natural form of vitamin K2 derived from Orange Jasmine (Murraya paniculata), leaf geraniol extract. As a nutrient, MK4 has many positive effects on the body. Research on MK4 (45 mg/day taken in divided doses) show that it builds stronger bones and promotes healthy blood production in people with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).
Bone Support and Fracture Reduction: Two meta-analyses of clinical trials on MK4 in people with osteoporosis concluded that MK4 (45 mg/day) reduces fracture risk. One of the studies determined that MK4 (45 mg daily) can decrease vertebral fracture risk by 60% and all nonvertebral fractures by 76% (Cockayne S et al. Arch Intern Med. 2006;166(12):1256-1261).
A more recent study published in 2015 evaluated 19 randomized, controlled clinical trials involving 6,759 volunteers. The researchers reached the same conclusion that MK4 (45 mg/day) can reduce fractures in women with osteoporosis (Huang ZB et al. Osteoporosis International. 2015;26(3):1175-1186).
Cancer Support: The US FDA reviewed the research on MK4 (45 mg/day) for people with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The FDA concluded that MK4 has the potential to treat these diseases, and awarded Dr. Neustadt’s company, NBI Pharmaceuticals, Inc. Orphan Drug Designation for MK4 for AML and MDS. As a dietary supplement, MK4 is not approved as a medication to diagnose, treat, prevent or cure any disease, but it can be taken as a dietary supplement to support healthy cell function.
SAFETY: Clinical trials published in medical journals document more than 7,000 people (view tables summarizing these studies) taking 45 mg daily (and higher doses) of MK4 for up to eight years without any serious side effects. The US Institutes of Medicine (IOM) states that natural vitamin K, which includes MK4, has no known “tolerable upper limit,” which means it’s considered safe even in doses much higher than that found in Osteo-K and Osteo-K Minis.
CAUTION: People taking the anticoagulant medication warfarin (Coumadin) should not take this product since vitamin K interferes with this medication.
180 capsules per bottle, a 30-day supply
More than 100 citations support the ingredients in Osteo-K and Osteo-K Minis for bone health, cardiovascular health and cancer support.
Gluten Free | Corn Free | Soy Free | Dairy Free
My labs have shown improvements just two months after beginning Osteo-K.
Thank you for your review. That's wonderful that Osteo-K has helped you so quickly.
This is an amazing product! I was diagnosed with the beginning of osteoporosis. I was afraid to take the shot or meds that were recommended to me. I decided to try Osteo K. It took a few weeks to see that it was working. My back goes out off and on so I was hoping this would help. I am so pleased to say this works! Thank you NBI.
Thank you for the review.
Ten years (??) ago, my naturopath at People’s Pharmacy in Austin recommended Osteo-K for my osteoporosis. I’ve been using it ever since. My last bone density test showed improvement in all areas.
Thank you for sharing your experience with Osteo-K. Congratulations on your bone density improving! That’s wonderful, and right in line with what the research shows about the nutrients in Otseo-K.
I’ve been using osteo k for 6 years in conjunction with high doses of D and fish oil. My bone density tests have gone from osteoporosis to osteopenia
Thank you for the review. We’re glad the product is helping you and helping you grow stronger bones.
My lumbar bone density improved from sd -2.2 to -1.7.
Thank you for leaving a review and sharing your experience with Osteo-K.
Been using this for some time now. DEXA showed 3.4% increased bone mass. Am 71 yrs.
Thank you for your review and sharing your results.
I began my journey of using medication to preserve and strengthen my bones in the Spring of 2002 which were ordered by my Rheumatologist @ Ohio State University. First, Fosamax weekly for 7 years. The side effects were harsh and made me uncomfortable for the whole day when I would take it. My Rheumatologist suggested that I take Reclast for the for the first time on 6/13, 2008. This was an IV infusion once a year, with minimal side effects. I did well with this medication and took it once a year for the next four years with no side effects and good maintenance of my BMD studies. (6/13/2008-9/12/2011). In 2012 I experienced significant dental trauma and consulted with my rheumatologist concerning the risk of developing osteonecrosis of the jaw if I continued using the bisphosphonate medication at the same time I was having to dental implants to repair and replace my 2 extracted teeth. The endodontist doing my implants introduced me to Dr. John Neustadt and NBI, and the research and success his patients and staff had with their BMD and a decrease in bone fractures. After reviewing the literature for Osteo K, I decided to take it as my Calcium supplement and not take any other medications for my bone health. I have been on Osteo K since Nov., 2014 and have good success in maintaining my bone density numbers, good healing of my dental implants, and good healing of the fractures that I incurred due to two hard falls. I have not had any spontaneous fractures. I am very pleased with the outcomes of my Osteo K supplementation these past, six years and have not experienced any adverse side effects. Dr. Neustadt has be extremely helpful in helping me navigate my journey toward improved BMD numbers and decrease fracture risk. I appreciate his genuine kindness and concern for my well being. Due to my success with Osteo K supplementation, my 82 year old sister is now also taking Osteo K as her Calcium supplement.
Thank you for your review. It's wonderful to read how helpful Osteo-K has been and how important it's been for your health. Thank you for sharing your story so others can read how the product might help them too.
I am in osteoporosis. Osteo K, along with Prolia is helping me stay healthy!! Thanks to all!
We're so glad Osteo-K is helping you. Thank you for your review and for sharing your experience.
Good product but in quantity for big savings
Thank you for your review. We're glad you like the product and it's helping you.
Looked the product. Order and shipping went well