Don’t be fooled - 3 crucial bone-health nutrients to look for in your supplements

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"Bone production is up, resorption is down…I will never stop taking Osteo-K!"
Donna, Osteo-K Customer

  • As we get older, we become increasingly concerned about things we’ve never really thought about before. One of those is our bones. We wonder things like: “Are they strong enough to grow old?”, “Can I continue being active?”, “Will I be able to enjoy my kids and grandkids?” The most important question to ask next is, “What can I do to keep my bones strong?”

With all of these questions, it’s only natural to give your bone health a boost with supplements. In fact, bone health supplements are so popular that Americans spend $10 billion a year on them. With so many different products available, how can you be sure that your money is being well-spent?

The goal of this article is to make sure that you’re using nutrients that are safe and have been clinically proven to promote bone health and maintain strong bones.  

Here’s what to look for—and what to avoid—in your bone health supplement.

Calcium and Vitamin D

When most people think of bones, they think of calcium and vitamin D.

The FDA has even approved the health claim for calcium and vitamin D, “Adequate vitamin D and calcium throughout life, as part of a well-balanced diet, may reduce the risk of osteoporosis.”

But do calcium and vitamin D promote healthy bone density and maintain strong bones? Yes, they do, but “it’s complicated”.

Here’s why: Research has shown that calcium and vitamin D3, when taken together, support healthy bone density and help maintain strong bones. This was indicated by about 18% fewer fractures in the study volunteers.

However, not all forms of calcium are equally absorbed or used by the body. There are two primary forms of calcium in supplements.

One is calcium carbonate. This form is most frequently used in clinical research and dietary supplements because it’s cheap. However, it’s also the least absorbable form.

For your body to absorb this form of calcium, it has to break it apart from the carbonate. Doing that requires stomach acid.

No problem, right? Wrong.

The older you get, the more likely it is that you’re producing less stomach acid.

This means that as you age, you aren’t able to absorb as much bone-strengthening calcium from calcium carbonate, right when you need it most.

It also means that the money you spend on a supplement with calcium carbonate is likely going to waste.

In contrast, calcium citrate does not require stomach acid for absorption and is 24% more absorbable than calcium carbonate.

That’s why we only use calcium citrate in Osteo-K and Osteo-K Minis, along with a healthy amount of vitamin D3 shown to support healthy vitamin D levels and maintain strong bones.

“After 18 months of taking Osteo-K, my family doctor called the results remarkable” - Percy Allen, Osteo-K Customer


MK4 and MK7 are two types of vitamin K2 used in dietary supplements. However, MK4 is the most researched form of vitamin K2 for bone health, and it’s the only one with an approved bone health claim from the Ministry of Health in Japan. 

In fact, MK4 has been so well-studied over the last 30 years that it’s been used in more than 25 clinicals trials with over 7,000 volunteers. These studies clearly show that MK4 (45 mg/day in divided doses) is safe, promotes healthy bone mineral density, and maintains bone strength.

This was indicated by 70% fewer fractures in people taking the nutrient. And if that weren’t enough, MK4 also enhances the ability of Vitamin D to add minerals to bone.

Despite being inferior, many other companies use MK7 because it’s cheap, but it simply is not as powerful as MK4 and not as well-researched.

That’s why Osteo-K and Osteo-K Minis only use MK4 in the clinical dose of 45 mg/day.

“I reviewed the research on the health effects of 45mg/day of MK4. I’m extremely impressed. I recommend my patients take Osteo-K to protect their bones.” - Mick Lifson, MD


(Avoid this mineral in your bone health supplement)

Strontium is a mineral used in some bone health dietary supplements.

While strontium has been shown in clinical trials to support healthy bone density and maintain strong bones, you should think twice before taking this nutrient.

Strontium, like calcium, accumulates in bones.

However, unlike calcium, strontium creates false bone density test results.

Therefore, while your test may look better, it may not actually be better. Strontium also may compete with calcium for absorption and decrease the amount of calcium your body can use. Additionally, strontium has been linked to an increased risk for dangerous blood clots in the lungs and heart attacks.

For all these reasons, Osteo-K and Osteo-K Minis DO NOT contain strontium.

“My physician was amazed that my bone density test was so good. I attribute that all to Osteo-K. It’s been a life changer for me in a positive way.” - Joan Anderson, Osteo-K Customer 


“My joints feel better; improved skin, nails & hair; better sleep" - Donna, Collagen Customer

Collagen is the most abundant protein in the body.

It’s the scaffolding that holds your body together. It’s so strong that it’s five to ten times stronger than steel.

You might be familiar with some of the benefits of collagen:
- Healthier Hair
- More Vibrant, Younger-looking Skin with Fewer Wrinkles
- Strong Fingernails
- Healthier Bones and Joints

A review of over 60 scientific studies on collagen found that supplementing with collagen peptides promotes healthy tissue regeneration, collagen synthesis and supports healthy joints, bone density and skin.

NBI Collagen powder meets or exceeds the amount of collagen used in clinical trials. Our carefully selected raw material doesn’t contain any of the bad stuff:

- Paleo Friendly
- Keto Friendly
- Non-GMO
- Gluten Free
- Unflavored
- Hydrolyzed types I and III collagen from grass-fed, pasture-raised cows
- Absolutely no antibiotics, hormones, pesticides, or solvents.

Get All Of These Nutrients With Osteo-K!

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Osteo-K Frequently Asked Questions

General Osteo-K Questions

Q: Does Osteo-K contain MK4?
Yes, plus other important nutrients for bone health. Each six capsules of Osteo-K contain 45 mg of MK4, a form of vitamin K2, 1000 mg calcium (citrate) and 2000 units Vitamin D3.

Q: What is the source of MK4 in your products?
NBI’s MK4 is derived from Orange Jasmine (Murraya paniculata), leaf geraniol extract.

Q: Who created Osteo-K?
Osteo-K, a bone support dietary supplement, was created by physicians from Harvard, Cornell, MIT and Bastyr. After years of Dr. Steve Pieczenik’s wife taking Fosamax without any benefit, and with painful side effects, he and his partner, Dr. John Neustadt began researching natural ways women and men can promote their bone health.

Q: How is Osteo-K different from other bone support formulas?
Osteo-K is the only osteoporosis supplement that contains the amount (45 mg) and form of vitamin K (MK4) plus calcium and vitamin D shown in clinical trials to prevent fractures.

Q: Is Osteo-K gluten free?
Yes. All of our NBI dietary supplements are completely gluten free.

Q: Are the Osteo-K capsules vegetarian?
Yes. All our capsules are 100% vegetarian cellulose capsules.

Q: Why doesn’t Osteo-K contain strontium?
For several reasons. First, clinical trials show that MK4 decreases fractures better than strontium–81% for MK4 versus 44% for strontium. Second, strontium decreases calcium absorption, and calcium is an important nutrient. Third the form of strontium used in all the clinical trials is strontium ranelate. Currently strontium ranelate is only available in Europe. Strontium in the US is available as strontium citrate, which has never been studied and shown to decrease fractures. Finally, strontium interferes with bone density scans and provides false results. The question of strontium and osteoporosis is a good one, but the research at this time supports MK4 over strontium.

Who Should Take Osteo-K?

Q: Should I take Osteo-K?
If you are concerned about your bone health, and are not taking Coumadin (warfarin), you should take Osteo-K.

Q: Can everyone take Osteo-K?
No. People taking warfarin (Coumadin) cannot take Osteo-K because the vitamin K in the dietary supplement will interfere with the warfarin.

Osteo-K, Calcium and Your Other Supplements

Q: Does Osteo-K interact with any other dietary supplements?
No. However, if you are taking different dietary supplements that also contain vitamin D and minerals, there is always a risk of taking too much vitamin D and too many minerals at the same time. Taking too many minerals can cause a watery diarrhea, technically called osmotic diarrhea. Simply taking Osteo-K away from other dietary supplements can correct this situation. If taking more than 100 mcg (4000 IU) vitamin D daily. Vitamin D blood level monitoring is recommended.

Q: Does Osteo-K replace my calcium supplement?
Yes. Because Osteo-K combines three of the most important micronutrients needfor bone health into one formd eula it’s the only dietary supplement you need for bone health. You don’t need to buy extra calcium unless advised to do so by your healthcare provider.

Q: Do I need to take extra vitamin D if I’m taking Osteo-K?
Only if your doctor has prescribed higher amounts of vitamin D than what is in Osteo-K. The total daily recommended amount (six capsules total divided into two servings) of Osteo-K contains 2,000 units of vitamin D3.

Osteo-K and Drug Interactions

Q: Will the MK4 in Osteo-K interact with heparin?
No. MK4 does not interact with heparin.

Q: If I’m taking aspirin, can I still take Osteo-K?
Yes. None of the ingredients in Osteo-K, including MK4, interfere with the effects of aspirin.

Q: If I’m taking warfarin (Coumadin), can I still take Osteo-K?
No. Vitamin K, which is in Osteo-K, will interfere with warfarin (Coumadin). Warfarin works to prevent blood clots by blocking how the body uses vitamin K to form blood clots. Taking vitamin K while taking warfarin overrides this mechanism and makes warfarin less effective. People taking warfarin absolutely cannot take Osteo-K.

Q: Can I take Osteo-K with my osteoporosis medication?
Yes. The ingredients in Osteo-K are safe to take with osteoporosis medications.

MK4, Healthy Bones and Bone Strength

Q: Does Osteo-K contain MK4?
Yes. Osteo-K contains the amount of MK4 used in clinical trials, plus calcium and vitamin D3.

Q: What is MK4 and how does it work?
MK4 is a form of vitamin K2 and the principal ingredient in Osteo-K. MK4 works by activating genes involved in promoting bone health through the formation of bone collagen and bone mineralization. These genes include growth differentiation factor 15 (GDF15), Stanniocalcin, Tenascin-c and bone morphogenic protein-2 (BMP-2). Only MK4 has been shown to activate all these genes.

Q: Has MK4 been shown to maintain bone strength?
Yes. In clinical trials MK4 (45 mg/day when taken in divided doses) has been shown to be an important nutrient for bone health. More than 25 clinicals trials with over 7000 volunteers conclude that MK4 (45 mg/day) maintains strong bones.

Q: Is MK4 a drug?
No. MK4 is a naturally occuring form of vitamin K2 and is a dietary supplement. It has not been approved by the FDA to prevent, treat or cure any disease.

Q: Is 45 mg of MK4 safe?
Vitamin K is important for healthy blood clotting. However, taking extra vitamin K does not increase your risk. Studies have shown that taking in excess of even 135 mg/day of MK4 does not increase blood clot risk. That’s because once the body has enough vitamin K for normal clotting, it cannot use more. NOTE: If you are at increased risk of blood clots and are taking warfarin (Coumadin), MK-4 counteracts the intended action of this medication.

Q: How does MK4 compare with MK7?
MK4 and MK7 are forms of vitamin K2. The health benefits of MK4 have been researched for more than thirty years and it’s the most-studied form of vitamin K2 for bone health. Only MK4 has been shown to maintain strong bones; support brain, liver and immune health; and promote healthy bone marrow and blood cell production.

Q: How does MK4 compare with strontium?
MK4 clinical trials compared to strontium clinical trials showed that MK4 had a superior ability to support healthy bones.

Q: Will I maintain strong bones if I take MK4?
Studies show that MK4 can help support strong bones in clinical trials that compared people taking 45 mg per day of MK4 to people not taking MK4.

Disclaimer: The information provided on this website is for educational purposes only and does not constitute medical advice; the Content is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a physician or other qualified healthcare professional with questions you may have regarding a medical condition.

These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.

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