Osteo-K, Osteo-K Minis, or Osteo-MK4
- Maintains strong bones
- Supports healthy bone density and bone matrix
- Promotes healthy bone marrow
- Supports immune system health and healthy inflammation balance
Since not everyone needs the same amount of calcium as a dietary supplement, we offer three options, all backed by our “Strong Bones” Guarantee.
In addition to MK4 and vitamin D3, Osteo-K® provides 1000 mg of calcium daily, Osteo-K Minis 400 mg of calcium, while Osteo-MK4 ® is our calcium-free option. If you're unsure which product is right for you, click here.
Clinical Trials: More than 25 clinical trials involving over 7000 people show that MK4 (45 mg/day in divided doses) promotes healthy bone density and maintains strong bones.
One review of data from 19 randomized, controlled clinical trials involving 6,759 volunteers reached the same conclusion: MK4 (45 mg/day in divided doses) maintains bone strength (Huang ZB et al. 2015;26(3):1175-1186).
A more recent systematic review and meta-analysis published in 2022 confirmed these findings. This study pooled data from 10 randomized, controlled clinical trials with 5,413 women ages 45-81. The data showed that clinical trial volunteers taking MK4 had better bone density and stronger bones than those who did not take the nutrient (Ma ML et al. 2022;10:979649).
Studies show that combining MK4 with vitamin D3 provides greater benefits than taking MK4 alone. A two-year clinical trial with 172 women (average age 53 years) divided the volunteers into four groups. They took MK4 (45 mg/day) alone, vitamin D3 alone, or MK4 plus vitamin D3. The fourth group served as a control and received only dietary counseling. All women had low bone mineral density at the beginning of the study.
Bone mineral density increased significantly more in the MK4+D3 group than in the other groups, and this improvement was evident after just six months of taking the nutrients. After two years, 67.8% of volunteers taking MK4+D3 had a bone density increase of 2% or more, while 45.2% had a 5% or greater increase (Ushiroyama T et al. 2002;41(3):211-221).
Another two-year randomized clinical trial divided 92 women (mean age about 64) into four groups. The women took MK4 (45 mg/day) alone, vitamin D3 alone, MK4 (45 mg/day) plus vitamin D3, or calcium alone (as calcium lactate, 2 grams/day). The best results were noted in the volunteers who took MK4 plus D3. In this group, bone density increased 1.49% during the first year and 1.35% after two years. (Iwamoto J, et al. 2000;5(6):546-51.)
A third clinical trial showed MK4 was the key additional nutrient. The study lasted six months and gave 78 women ages 61 to 74 either MK4 (45 mg/day), vitamin D3 and calcium, or only vitamin D3 and calcium. Only those taking MK4 showed increased bone density. (Je SH, et al. 2011;26(8):1093-8.)
Safety: Clinical trials published in medical journals document over 7,000 people taking 45 mg daily (and higher doses) of MK4 for up to eight years without any serious side effects.
CAUTION: People taking the anticoagulant medication warfarin (Coumadin) should not take this product since vitamin K interferes with this medication.
Directions: Take one capsule twice daily with meals.
Each bottle contains a 30-day supply when taken as directed.
References: More than 100 citations support Osteo-K, Osteo-K Minis, and Osteo-MK4 ingredients for bone health, cardiovascular health, and immune support.
Collagen
Collagen is the most abundant protein in the body. It forms the scaffolding that provides strength and flexibility to your skin, nails, bones, joints, and organs. Babies’ skin is plump, soft, and bounces right back because they have lots of healthy collagen. But as people age, supplementing with collagen can promote joint and bone health and support healthy skin hydration and elasticity.
NBI’s Collagen delivers 10 grams of non-GMO, unflavored, hydrolyzed Types I and III collagen to promote healthy skin, bones, joints, and nails. It's paleo- and keto-friendly and derived from grass-fed, pasture-raised cows.
Our collagen powder matches or exceeds the amount of collagen used in clinical trials for bone, joint, and skin health.
Each bottle contains a 30-day supply.
Recommended use: One scoop per day in coffee, tea, or a drink of your choice, or add it to your favorite smoothies or food.
Want more recipe ideas? Download the free Collagen eBook.