To meet the unique nutritional needs of different people, NBI has created two versions of Osteo-K, the original Osteo-K® formula and Osteo-K Minis (with less calcium). If you're not sure which product is right for you, click here.
Osteo-K delivers 45 mg of MK4® (menaquinone-4) per day in divided doses to more closely match the clinical trials, plus calcium (1000 mg/day) and vitamin D (2000 IU/day).
NBI's MK4 is a natural form of vitamin K2 derived from Orange Jasmine (Murraya paniculata), leaf geraniol extract. As a nutrient, MK4 has many positive effects on the body. Research on MK4 (45 mg/day taken in divided doses) show that it builds stronger bones and promotes healthy blood production in people with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).
Bone Support and Fracture Reduction: Two meta-analyses of clinical trials on MK4 in people with osteoporosis concluded that MK4 (45 mg/day) reduces fracture risk. One of the studies determined that MK4 (45 mg daily) can decrease vertebral fracture risk by 60% and all nonvertebral fractures by 76% (Cockayne S et al. Arch Intern Med. 2006;166(12):1256-1261).
A more recent study published in 2015 evaluated 19 randomized, controlled clinical trials involving 6,759 volunteers. The researchers reached the same conclusion that MK4 (45 mg/day) can reduce fractures in women with osteoporosis (Huang ZB et al. Osteoporosis International. 2015;26(3):1175-1186).
Cancer Support: The US FDA reviewed the research on MK4 (45 mg/day) for people with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The FDA concluded that MK4 has the potential to treat these diseases, and awarded Dr. Neustadt’s company, NBI Pharmaceuticals, Inc. Orphan Drug Designation for MK4 for AML and MDS. As a dietary supplement, MK4 is not approved as a medication to diagnose, treat, prevent or cure any disease, but it can be taken as a dietary supplement to support healthy cell function.
SAFETY: Clinical trials published in medical journals document more than 7,000 people taking 45 mg daily (and higher doses) of MK4 for up to eight years without any serious side effects. The US Institutes of Medicine (IOM) states that natural vitamin K, which includes MK4, has no known “tolerable upper limit,” which means it’s considered safe even in doses much higher than that found in Osteo-K and Osteo-K Minis.
CAUTION: People taking the anticoagulant medication warfarin (Coumadin) should not take this product since vitamin K interferes with this medication.
180 capsules per bottle, a 30-day supply
More than 100 citations support the ingredients in Osteo-K and Osteo-K Minis for bone health, cardiovascular health and cancer support.
Gluten Free | Corn Free | Soy Free | Dairy Free
This was recommended to me by my Naturopathic doctor. Ordering was easy, and items were shipped in a timely fashion. I need bone support due to some immunotherapy medications I am taking for Stage 4 cancer. Hopefully this is the right choice.
Thank you for leaving your review. I'm honored that Osteo-K is part of your health program. All of us here hope your treatments go well and we wish you a full recovery.
I have used this product for about 5 years and have reversed my osteoporosis! I again now have osteopenia -- at 74 years of age.
Congratulations on reversing your osteoporosis. I'm happy that Osteo-K can be part of your bone health solution and that it helped you. Thank you for leaving a review.
I have been using for years, and my bone density keeps improving .
That's fantastic! Thank you for sharing your results and providing review.
I have been taking Osteo-K for years. I refused to take osteoporosis drugs and opted to take Osteo-K. One military physician dismissed me from care because of this. The next one who got me as their patient was amazed at how Osteo-K and weight resistance exercise held it at bay and I even gained some bone density. I am so grateful and a customer for life!
Thank you for leaving your review. It’s wonderful to read how your doctor is so happy with how your bones are doing.
Easy to order easy to get around on your website And arrived in a timely way
Thank you for your leaving your review. I'm glad you had a great ordering experience.
My interactions have always been positive & a joy with N.B.I. Every 3 months I call to reorder my Osteo. K. All NBI employees are polite extremely helpful. Thanks to D.R. Neusteadt, a radio program, and a cousin who recorded it for me Osteo-K (mk4) has kept me on my feet moving and pain-free. Before Osteo-K I could barely walk , enormous pain. Very depressed. 1week later. No more pain no more limping no more sadness. That is how fast-it.worked. Because of all of the above I know I can count on this product to help to get me through every day. Osteoperosis,Osteoarthritis, arthritis. OsteoK(MK4) takes care of it all. I will always be thankful.
Thank you for your review. We're thrilled to read how happy you are with NBI and Osteo-K, and how much the product has helped you.
Osteo-K has helped keep my bone density stable over the past 2 years.
Thank you for sharing your experience and for putting your faith in NBI and Osteo-K. But the proof is in the bone density scans, and I'm thrilled that you've seen the benefits.
Let me tell you I have been on Osteo k for 10 years and my bone density has improved every time. I am disappointed that I never get a code for a discount. I have given you at least 3 or 4 new clients and I can name them for you. You need to hear my success story. I am now 72 years old.
That's fantastic that you continue to experience the benefits of Osteo-K. And thank you for telling your friends about the product. I'm sorry your haven't been receiving our discount codes. When we have sales, we send the coupon codes out in our newsletters. I noticed that you are subscribed to our newsletter. Please make sure that they aren't going into your spam folder, because you should be receiving them. If you continue to have difficulty, contact our customer service team and we'll be happy to help you. Their email is firstname.lastname@example.org.
Osteo-K is the best addition to my bone health. Other forms of Vitamin K are a waste of money and do nothing to address the cause of weak bones due to age. I'm pleased that the Japanese people have shared this. American drug companies don't recognize anything they can't make money on. And so, people like me pay the price. Thank you for this product. My last scan showed improvement! I order large numbers of bottles so I never run out. Keep up the good work!!
Everyone here was excited to learn about your results and how much help Osteo-K has given you. Thank you for sharing your experience with Osteo-K.
I've been using this for 10 years. It has helped with my over-all health and bone density. It's been a "life-saver!"
Thank you for leaving a review and sharing how Sleep Relief has helped you.