Thyroid Antibodies (Anti-TPO and Anti-TG)
Autoimmune hypothyroid disease, called Hashimoto Thyroiditis, is characterized by the body’s own immune proteins attacking the thyroid gland. This test detects levels of those antibodies to see if an autoimmune disease against the thyroid gland is present.
In the early stages of Hashimoto thyroiditis, thyroid hormone levels can be normal. Over time, however, as the immune system begins to destroy the thyroid gland and reduce the amount of thyroid hormone. This results in hypothyroid symptoms, such as fatigue, depression, decreased libido and weight gain.
Doctors test the anti-thyroglobuin (Anti-TG) and anti-thyroperoxidase (Anti-TP) antibodies to diagnose Hashimoto thyroiditis. Additionally, Anti-TG can be useful in the diagnosis and management of Graves' disease (hyperthyroid), certain types of goiter and to monitor patients who have had their thyroid gland removed because of thyroid cancer.
Alternate names: Thyroid antithyroglobulin antibody (ATA), Thyroid peroxidase antibody (TPO), Anti-Thyroid Microsomal Antibody
- Anti-thyroglobulin antibody (Anti-TG)
- Anti-thyroperoxidase antibody (Anti-TPO)
Methodology: Immunoassay (IA)
Water: Drink plenty of water to stay well hydrated.
Medications: Take all medications as prescribed.
3-5 business days
Result turnaround times are estimates and not guaranteed. Due to factors outside of our control, such as weather, holidays, confirmation/repeat testing or equipment maintenance, our lab may require additional time to complete tests.
Top Reasons to Test Your Thyroid, by Dr. John Neustadt
Hypothyroidism (Mayo Clinic)
Hyperthyroidism (Mayo Clinic)
Gaitonde DY, Rowley KD, Sweeney LB. Hypothyroidism: an update. Am Fam Physician. 2012;86(3):244-251.
LeFevre ML, Force USPSTF. Screening for thyroid dysfunction: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2015;162(9):641-650.