Oxidized LDL (oxLDL) Cholesterol
Oxidized LDL (oxLDL) has been studied for more than 30 years. Since the discovery of oxidized LDL, over 5,000 articles have appeared on the topic with over. OxLDL has emerged as a risk factor for heart disease, fatty liver and cancer, and is associated with a pro-inflammatory Wester Diet (the Standard American Diet). Running an oxLDL test can provide important information about your health.
- Oxidized Low-density Lipoprotein (oxLDL)
Methodology: Enzyme Linked Immunosorbent Assay (ELISA)
Fasting: Fast for 10 to 12 hours.
Water: Drink plenty of water to stay well hydrated.
Medications: Take all medications as prescribed.
5-7 business days
Result turnaround times are estimates and not guaranteed. Due to factors outside of our control, such as weather, holidays, confirmation/repeat testing or equipment maintenance, our lab may require additional time to complete tests.
Damage of low density lipoproteins (LDL) by free radicals creates oxidized low density lipoproteins (oxidized LDL) and is a key event in starting and promoting the development of atherosclerosis (hardening of the arteries) and heart disease. Oxidized LDL is found in arteries with atherosclerosis but not in healthy arteries.
Free radical damage may play an important role in the development of many other conditions, including cancer and liver disease such as non-alcoholic steatohepatitis (NASH). OxLDL has emerged as a potential risk factor.
Elevated Ox-LDL is associated with accelerated hardening of the arteries (atherosclerosis), coronary artery disease (CAD), heart attack (myocardial infarction), and chest pain (angina). It’s also been associated with pre-diabetes, metabolic syndrome, insulin resistance and hypothyroidism.
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Heinecke JW. Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis. Atherosclerosis. 1998 Nov;141(1):1-15.
Parthasarathy S, Raghavamenon A, Garelnabi MO, Santanam N. Oxidized low-density lipoprotein. Methods Mol Biol. 2010;610:403-417.
Steinberg D. Lewis A. Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis. Circulation. 1997 Feb 18;95(4):1062-1071.
Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem. 1997 Aug 22; 272(34):20963-20966.
Walenbergh SM, Koek GH, Bieghs V, Shiri-Sverdlov R. Non-alcoholic steatohepatitis: the role of oxidized low-density lipoproteins. J Hepatol. 2013;58(4):801-810.
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