Celiac disease is one of the most common autoimmune gastrointestinal disorders. Estimates show that it may affect up to 1% of the population and has been increasing steadily over the last 50 years. Signs and symptoms of celiac disease are nonspecific and can vary greatly from person to person. Testing for celiac disease can help people understand if they need to follow a gluten-free diet.
- Tissue Transglutaminase (tTG) Antibodies (IgG, IgA)
- Gliadin (Deamidated Peptide) Antibody (IgG, IgA)
- IgA (Immunoglobulin A)
Fasting: No required.
Water: Drink plenty of water to stay well hydrated.
Medications: Take all medications as prescribed.
5-7 business days
Result turnaround times are estimates and not guaranteed. Due to factors outside of our control, such as weather, holidays, confirmation/repeat testing or equipment maintenance, our lab may require additional time to complete tests.
Celiac disease occurs when the immune system reacts to the dietary protein gluten. Gluten is a common. It’s found in wheat, rye, barley, triticale, malt and others. The manifestations of celiac disease range from no symptoms to overt malabsorption with involvement of multiple organ systems and an increased risk of some cancers. More than 75% of patients with untreated celiac disease develop osteoporosis, and celiac disease is known to increase fracture risk.
People with celiac disease frequently experience:
- Borborygmus (a rumbling or gurgling noise made by the movement of fluid and gas in the intestine)
- Abdominal pain
- Weight loss
However, the disease can affect systems throughout the body. Celiac disease can affect the skin, liver, nervous system, bones, reproductive system, and endocrine system. The skin disorder, dermatitis herpetiformis, occurs in 10 to 20 percent of patients with celiac disease.
The Aamerican Gastroenterological Association Institute recommends the people with the following conditions consider getting screened for Celiac Disease:
- Autoimmune hepatitis
- Down syndrome
- Premature onset of osteoporosis
- Primary biliary cirrhosis
- Unexplained elevations in liver transaminase levels
- Unexplained iron deficiency anemia
- Autoimmune thyroid disease Cerebellar ataxia
- First- or second-degree relative with celiac disease
- Irritable bowel syndrome
- Peripheral neuropathy
- Recurrent migraine
- Selective immunoglobulin A deficiency Short stature (in children)
- Sjögren’s syndrome
- Turner’s syndrome
- Type 1 diabetes mellitus
- Unexplained delayed puberty
- Unexplained recurrent fetal loss
Corazza GR, Di Sario A, Cecchetti L, et al. Bone mass and metabolism in patients with celiac disease. Gastroenterology. 1995;109(1):122-128.
Leffler D. Celiac Disease Diagnosis and Management. JAMA: The Journal of the American Medical Association. 2011;306(14):1582-1592.
Presutti RJ, Cangemi JR, Cassidy HD, Hill DA. Celiac disease. Am Fam Physician. 2007;76(12):1795-1802.